KEGG   Homo sapiens (human): 28996
Entry
28996             CDS       T01001                                 
Symbol
HIPK2, PRO0593
Name
(RefSeq) homeodomain interacting protein kinase 2
  KO
K08826  homeodomain interacting protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04218  Cellular senescence
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    28996 (HIPK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    28996 (HIPK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     28996 (HIPK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CMGC group
  DYRK family [OT]
   28996 (HIPK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo Pkinase_fungal Pox_ser-thr_kin TCAD9 APH
Other DBs
NCBI-GeneID: 28996
NCBI-ProteinID: NP_073577
OMIM: 606868
HGNC: 14402
Ensembl: ENSG00000064393
UniProt: Q9H2X6
Structure
Position
7:complement(139561570..139777998)
AA seq 1198 aa
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
NT seq 3597 nt   +upstreamnt  +downstreamnt
atggcccccgtgtacgaaggtatggcctcacatgtgcaagttttctcccctcacaccctt
caatcaagtgccttctgtagtgtgaagaaactgaaaatagagccgagttccaactgggac
atgactgggtacggctcccacagcaaagtgtatagccagagcaagaacatccccctgtcg
cagccagccaccacaaccgtcagcacctccttgccggtcccaaacccaagcctaccttac
gagcagaccatcgtcttcccaggaagcaccgggcacatcgtggtcacctcagcaagcagc
acttctgtcaccgggcaagtcctcggcggaccacacaacctaatgcgtcgaagcactgtg
agcctccttgatacctaccaaaaatgtggactcaagcgtaagagcgaggagatcgagaac
acaagcagcgtgcagatcatcgaggagcatccacccatgattcagaataatgcaagcggg
gccactgtcgccactgccaccacgtctactgccacctccaaaaacagcggctccaacagc
gagggcgactatcagctggtgcagcatgaggtgctgtgctccatgaccaacacctacgag
gtcttagagttcttgggccgagggacgtttgggcaagtggtcaagtgctggaaacggggc
accaatgagatcgtagccatcaagatcctgaagaaccacccatcctatgcccgacaaggt
cagattgaagtgagcatcctggcccggttgagcacggagagtgccgatgactataacttc
gtccgggcctacgaatgcttccagcacaagaaccacacgtgcttggtcttcgagatgttg
gagcagaacctctatgactttctgaagcaaaacaagtttagccccttgcccctcaaatac
attcgcccagttctccagcaggtagccacagccctgatgaaactcaaaagcctaggtctt
atccacgctgacctcaaaccagaaaacatcatgctggtggatccatctagacaaccatac
agagtcaaggtcatcgactttggttcagccagccacgtctccaaggctgtgtgctccacc
tacttgcagtccagatattacagggcccctgagatcatccttggtttaccattttgtgag
gcaattgacatgtggtccctgggctgtgttattgcagaattgttcctgggttggccgtta
tatccaggagcttcggagtatgatcagattcggtatatttcacaaacacagggtttgcct
gctgaatatttattaagcgccgggacaaagacaactaggtttttcaaccgtgacacggac
tcaccatatcctttgtggagactgaagacaccagatgaccatgaagcagagacagggatt
aagtcaaaagaagcaagaaagtacattttcaactgtttagatgatatggcccaggtgaac
atgacgacagatttggaagggagcgacatgttggtagaaaaggctgaccggcgggagttc
attgacctgttgaagaagatgctgaccattgatgctgacaagagaatcactccaatcgaa
accctgaaccatccctttgtcaccatgacacacttactcgattttccccacagcacacac
gtcaaatcatgtttccagaacatggagatctgcaagcgtcgggtgaatatgtatgacacg
gtgaaccagagcaaaacccctttcatcacgcacgtggcccccagcacgtccaccaacctg
accatgacctttaacaaccagctgaccactgtccacaaccaggctccctcctctaccagt
gccactatttccttagccaatcccgaagtctccatactaaactacccatctacactctac
cagccctcagcggcatccatggctgcagtggcccagcggagcatgcccctgcagacagga
acagcccagatttgtgcccggcctgacccgttccagcaagctctcatcgtgtgtcccccc
ggcttccaaggcttgcaggcctctccctctaagcacgctggctactcggtgcgaatggaa
aatgcagttcccatcgtcactcaagccccaggagctcagcctcttcagatccaaccaggt
ctgcttgcccagcaggcttggccaagtgggacccagcagatcctgcttcccccagcatgg
cagcaactgactggagtggccacccacacatcagtgcagcatgccaccgtgattcccgag
accatggcaggcacccagcagctggcggactggagaaatacgcatgctcacggaagccat
tataatcccatcatgcagcagcctgcactattgaccggtcatgtgacccttccagcagca
cagcccttaaatgtgggtgtggcccacgtgatgcggcagcagccaaccagcaccacctcc
tcccggaagagtaagcagcaccagtcatctgtgagaaatgtctccacctgtgaggtgtcc
tcctctcaggccatcagctccccacagcgatccaagcgtgtcaaggagaacacacctccc
cgctgtgccatggtgcacagtagcccggcctgcagcacctcggtcacctgtgggtggggc
gacgtggcctccagcaccacccgggaacggcagcggcagacaattgtcattcccgacact
cccagccccacggtcagcgtcatcaccatcagcagtgacacggacgaggaggaggaacag
aaacacgcccccaccagcactgtctccaagcaaagaaaaaacgtcatcagctgtgtcaca
gtccacgactccccctactccgactcctccagcaacaccagcccctactccgtgcagcag
cgtgctgggcacaacaatgccaatgcctttgacaccaaggggagcctggagaatcactgc
acggggaacccccgaaccatcatcgtgccacccctgaaaacccaggccagcgaagtattg
gtggagtgtgatagcctggtgccagtcaacaccagtcaccactcgtcctcctacaagtcc
aagtcctccagcaacgtgacctccaccagcggtcactcttcagggagctcatctggagcc
atcacctaccggcagcagcggccgggcccccacttccagcagcagcagccactcaatctc
agccaggctcagcagcacatcaccacggaccgcactgggagccaccgaaggcagcaggcc
tacatcactcccaccatggcccaggctccgtactccttcccgcacaacagccccagccac
ggcactgtgcacccgcatctggctgcagccgctgccgctgcccacctccccacccagccc
cacctctacacctacactgcgccggcggccctgggctccaccggcaccgtggcccacctg
gtggcctcgcaaggctctgcgcgccacaccgtgcagcacactgcctacccagccagcatc
gtccaccaggtccccgtgagcatgggcccccgggtcctgccctcgcccaccatccacccg
agtcagtatccagcccaatttgcccaccagacctacatcagcgcctcgccagcctccacc
gtctacactggatacccactgagccccgccaaggtcaaccagtacccttacatataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (11)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (53)   
   RefSeq(nuc) (23)   
   GenBank (15)   
   EMBL (15)   
3D Structure (2)   
   PDB (2)   
Protein domain (7)   
   Pfam (7)   
All databases (111)   

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